研究業績

1. ShinsukeTamai, Shin-ichiro Fujita, Ritsuko Komine, Yasuharu Kanki, Kai Aoki, Koichi Watanabe, Kazuhiro Takekoshi, Takehito Sugasawa. Acute cold stress induces transient MuRF1 upregulation in the skeletal muscle of zebrafish. BBRC 2022

2. Kai Aoki, Fang Hui, Takehito Sugasawa, Yasuko Yoshida, Yasushi Kawakami, Kazuhiro Takekoshi. Alteration of gene and protein expression of renalase and its transcription factors in Caco-2 cell. International Journal of Analytical Bio-Science 2022

3. Kai Aoki, Takehito Sugasawa, Yasuko Yoshida, Yasushi Kawakami, Kazuhiro Takekoshi. Effects of doxorubicin-induced cell senescence on the expression of renalase in Caco-2 cell line. International Journal of Analytical Bio-Science 2022

4. Hui Fang, Kai Aoki, Katsuyuki Tokinoya, Masato Yonamine, Takehito Sugasawa, Yasushi Kawakami, Kazuhiro Takekoshi.Effects of High-Fat Diet on the Gut Microbiota of Renalase Gene Knockout Mice. Obesities 2022

5. Kai Aoki, Kei Ebina, Hana Shingu, Kazuki Kioka, Takehito Sugasawa, Yasushi Kawakami, Kazuhiro Takekoshi, Naomi Omi. Female athlete triad affects rat intestinal morphology and sucrase-isomaltase expression. The British journal of nutrition 2022

6. Hui Fang, Kai Aoki, Katsuyuki Tokinoya, Yasuko Yoshida, Masato Yonamine, Yasushi Kawakami, Kazuhiro Takekoshi. Fecal supernatant from renalase gene knockout mice weakens the AKT/JNK pathway to decrease the expression of Pc1/3 and Boc-Arg-Val-Arg-Arg-MCA cleaving activity in STC-1 cell line. International Journal of Analytical Bio-Science 2022

7. Takehito Sugasawa, Ritsuko Komine, Lev Manevich, Shinsuke Tamai, Kazuhiro Takekoshi, Yasuharu Kanki. Novel Insights of Fasting-Refeeding Response in Zebrafish Skeletal Muscle. Nutrients. 2022

8. Keisei Kosaki, Shota Kumamoto, Katsuyuki Tokinoya, Yasuko Yoshida, Takeshi Sugaya, Takayo Murase, Seigo Akari, Takashi Nakamura, Yoshiharu Nabekura, Kazuhiro Takekoshi, Seiji Maeda. Xanthine oxidoreductase activity in marathon runners: potential implications for marathon-induced acute kidney injury. J Appl Physiol (1985). 2022

9. Takehito Sugasawa, Yasuharu Kanki, Ritsuko Komine, Koichi Watanabe, Kazuhiro Takekoshi. Identification of RNA Markers in Red Blood Cells for Doping Control in Autologous Blood Transfusion. Genes (Basel). 2022

10. Koshiro Nishimoto, Noriaki Lukas Santo, Masato Yonamine, Kazuhiro Takekoshi, Go Kaneko, Suguru Shirotake, Hisayo Fukushima, Yoshitaka Okada, Masanori Yasuda, Akihiro Sakurai, Masafumi Oyama, Kento Kanao. Progressive metastatic pheochromocytoma induced by multiple endocrine neoplasia type 2A with a lethal outcome. IJU Case Rep. 2022

11. Kai Aoki, Masaki Konno, Katsuyuki Tokinoya, Katsunari Honda, Takuya Abe, Takeshi Nagata, Masaaki Takehara, Takehito Sugasawa, Kazuhiro Takekoshi, Hajime Ohmori. Long-Term Habitual Exercise and Combination of β-Hydroxy-β-Methylbutyrate plus Black Ginger Alter the Autophagy and Mitochondria Related Genes in SAMP8 Mice. J Nutr Sci Vitaminol (Tokyo). 2022

 研究室

1. Takehito Sugasawa, Shin-ichiro Fujita, Tomoaki Kuji, Noriyo Ishibashi, Kenshirou Tamai, Yasushi Kawakami, Kazuhiro Takekoshi. Dynamics of Specific cfDNA Fragments in the Plasma of FullMarathon Participants. Genes 2021
2. Kai Aoki, Takuji Suzuki, Fang Hui, Takuro Nakano, Koki Yanazawa, Masato Yonamine, Shinichiro Fujita Takehito Sugasawa, Yasuko Yoshida, Naomi Omi, Kazuhiro Takekoshi. Acute Low-Intensity Treadmill Running Upregulates the Expression of Intestinal Glucose Transporters via GLP-2 in Mice. Nutrients 2021
3. Takehito Sugasawa, Seiko Ono, Masato Yonamine, Shin-ichiro Fujita, Yuki Matsumoto, Kai Aoki, Takuro Nakano, Shinsuke Tamai, Yasuko Yoshida, Yasushi Kawakami, Kazuhiro Takekoshi. One Week of CDAHFD Induces Steatohepatitis and   Mitochondrial Dysfunction with Oxidative Stress in Liver. International Journal of Molecular Sciences 2021
4. Masato Yonamine, Koichiro Wasano, Yuichi Aita, Takehito Sugasawa, Katsutoshi Takahashi, Yasushi Kawakami, Hitoshi Shimano, Hiroyuki Nishiyama, Hisato Hara, Mitsuhide Naruse, Takahiro Okamoto, Tadashi Matsuda, Shinji Kosugi, Kazuhiko Horiguchi, Akiyo Tanabe, Atsushi Watanabe, Noriko Kimura, Eijiro Nakamura, Akihiro Sakurai, Kiyoto Shiga, Kazuhiro Takekoshi. Prevalence of Germline Variants in a Large Cohort of Japanese Patients with Pheochromocytoma and/or Paraganglioma. Cancers 2021
5. Takehito Sugasawa, Takuro Nakano, Shin-ichiro Fujita, Yuki Matsumoto, Genki Ishihara, Kai Aoki, Koki Yanazawa, Seiko Ono, Shinsuke Tamai, Lev Manevich, Haruna Ueda, Noriyo Ishibashi, Kenshirou Tamai, Yasuharu Kanki, Yasuko Yoshida, Koichi Watanabe, Tohru Takemasa, Yasushi Kawakami, Kazuhiro Takekoshi. Proof of Gene Doping in a Mouse Model with a Human Erythropoietin Gene Transferred Using an Adenoviral Vector. Genes 2021
6. Tomoaki Kuji, Takehito Sugasawa., Shin-Ichiro Fujita., Seiko Ono, Yasushi Kawakami, Kazuhiro Takekoshi. A Pilot Study of miRNA Expression Profile as a Liquid Biopsy for Full-Marathon Participants. Sports 2021

7. Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi. Development of a gene doping detection method to detect overexpressed human follistatin using an adenovirus vector in mice. PeerJ 2021

 研究室

1. Katsuyuki Tokinoya, Yasuko Yoshida, Takehito Sugasawa, Kazuhiro Takekoshi: Moderate-intensity exercise increases renalase levels in the blood and the skeletal muscle in rats. FEBS Open Bio, 2020.
2. Kai Aoki​​, Takehito Sugasawa​, Kouki Yanazawa, Koichi Watanabe, Tohru Takemasa, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuko Yoshida, Tomoaki Kuji, Nanami Sekine, Kaoru Takeuchi, Haruna Ueda, Yasushi Kawakami, Kazuhiro Takekoshi​: The detection of trans gene fragments of hEPO in gene doping model mice by Taqman qPCR assay. PeerJ, 2020.
3. Takehito Sugasawa, Tomoaki Kuji, Kai Aoki, Koki Yanazawa, Akiko Takenouchi, Makoto Watanabe, Yoshiya Tome, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuhiro Shishikura, Seikou Ono, Yasuko Yoshida, Yasushi Kawamai, Kazuhiro Takekoshi: Characterization of osteoarthritis in a medial meniscectomy-induced animal model using contrast-enhanced X-ray microtomography. Biomedicines, 2020
4. Takehito Sugasawa, Kai Aoki, Kouki Yanazawa, Kazuhiro Takekoshi: Detection of Multiple Transgene Fragments in a Mouse Model of Gene Doping Based on Plasmid Vector Using Taqman qPCR Assay. Genes, 2020
5. Kai Aoki, Masaki Konno, Katsuyuki Honda, Takuya Abe, Takeshi Nagata, Masaaki Takehara, Takehito Sugasawa, Kazuhiro Takekoshi, Hajime Ohmori: Habitual Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model. Geriatrics, 2020
6. Katsuyuki Tokinoya, Nanami Sekine, Kai Aoki, Seiko Ono, Tomoaki Kuji, Takehito Sugasawa, Yasuko Yoshida, Kazuhiro Takekoshi: Effect on fibrosis marker in nonalcoholic steatohepatitis in renalase deficient mice. Mol Med Rep, 2020
7. Kai Aoki , Koki Yanazawa , Katsuyuki Tokinoya , Takehito Sugasawa , Takuji Suzuki , Yasuko Yoshida , Takuro Nakano , Naomi Omi , Yasushi Kawakami, Kazuhiro Takekoshi: Renalase is localized to the small intestine crypt and expressed upon the activation of NF-κB p65 in mice model of fasting-induced oxidative stress. Life Sci, 2020

共同研究（著者）

1. Yoshida Y, Kosaki K, Sugasawa T, Matsui M, Yoshioka M, Aoki K, Kuji T, Mizuno R, Kuro-O M, Yamagata K, Maeda S, Takekoshi K. High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese Population. Nutrients. 2020 Nov 12;12(11):3474

 研究室

1. Tokinoya Katsuyuki, Shiromoto Jun, Sugasawa Takehito, Yoshida Yasuko, Aoki Kai, Nakagawa Yoshimi, Ohmori Hajime, Takekoshi Kazuhiro: Influence of acute exercise on renalase and its regulatory mechanism. Life Sciences, 210: 235-242, 2018.
2. 時野谷勝幸, 吉田保子, 菅澤威仁, 森田将平, 竹越一博: タウリン添加による代謝制御に関するマイオカインの応答. 4(1): 19-21, 2018（紀要）

共同研究（著者）

1. Tanaka K, Sasai H, Wakaba K, Murakami S, Ueda M, Yamagata F, Sawada M, Takekoshi K: Professional dietary coaching within a group chat using a smartphone application for weight loss: a randomized controlled trial. J Multidiscip Healthc,11:339-347, 2018. 
2. Tagawa K, Ra SG, Kumagai H, Yoshikawa T, Yoshida Y, Takekoshi K, Sakai S, Miyauchi T, Maeda S: Effects of resistance training on arterial compliance and plasma endothelin-1 levels in healthy men. Physiol Res, 67(Supplementum 1):S155-S166, 2018.
3. Naruse M, Satoh F, Tanabe A, Okamoto T, Ichihara A, Tsuiki M, Katabami T, Nomura M, Tanaka T, Matsuda T, Imai T, Yamada M, Harada T, Kawata N, Takekoshi K: Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan. Endocr J, 65(3):359-37, 2018.

 研究室

1. Tokinoya Katsuyuki, Takekoshi Kazuhiro: Effect of renalase on dexamethasone-induced muscle atrophy. International Journal of Analytical Bio-Science, 7(4), 2019.
2. Takehito Sugasawa†, Kai Aoki†, Koichi Watanabe, Koki Yanazawa, Tohru Natsume, Tohru Takemasa, Kaori Yamaguchi, Yoshinori Takeuchi, Yuichi Aita, Naoya Yahagi, Yasuko Yoshida, Katsuyuki Tokinoya, Nanami Sekine, Kaoru Takeuchi, Haruna Ueda, Yasushi Kawakami, Satoshi Shimizu, Kazuhiro Takekoshi : Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR. Genes (Basel) 10(6), 2019.

研究室

1. Yasuko Yoshida, Takehito Sugasawa, Katsuyuki Tokinoya, Namba Shunji, Kazuhiro Takekoshi: Epinephrine upregulates renalase expression in cultured C2C12 muscle cells, International Journal of Analytical Bio-Science, 5(4): 61-65. 2017.
2. Yasuko Yoshida, Takehito Sugasawa, Masaya Hoshino, Katsuyuki Tokinoya, Keisuke Ishikuram, Hajime Ohmori, Kazuhiro Takekoshi: Transient changes in serum renalase concentration during long-distance running: The case of an amateur runner under continuous training, The Japanese Society of Physical Fitness and Sports Medicine, 6(3): 159-166. 2017.
3. Takehito Sugasawa, Yasuko Yoshida, Katsuyuki Tokinoya, Kazuhiro Takekoshi: Conservative Treatment with Continuous Cryotherapy as a Japanese Judo Therapy for Jones Fracture: A Case Report, Journal of Trauma & Treatment, 6(4): 2017.

共同研究（著者）

1. Shibata M, Inaishi T, Miyajima N, Adachi Y, Takano Y, Nakanishi K, Takeuchi D, Noda S, Aita Y, Takekoshi K, Kodera Y, Kikumori T: Synchronous bilateral pheochromocytomas and paraganglioma with novel germline mutation in MAX: a case report. Surg Case Rep, 28;3(1):131, 2017.
2. Matsumura-Matsuda E, Sekiya M, Omoto-Inuzuka M, Santo K, Shikama A, Kuba M, Sugano Y, Iwasaki H, Yatoh S, Sato T, Hara H, Takekoshi K, Suzuki H, Shimano H: A Rare Coexistence of Pheochromocytoma and Parkinson's Disease With Diagnostic Challenges. Intern Med, 57(7):979-985, Epub 2017.
3. Saitoh K, Yonemoto T, Usui T, Takekoshi K, Suzuki M, Nakashima Y, Yoshimura K, Kosugi R, Ogawa T, Inoue T: Novel germline variant of TMEM127 gene in a patient with familial pheochromocytoma. Endocrinol Diabetes Metab Case Rep, 2017.
4. Misu H, Takayama H, Saito Y, Mita Y, Kikuchi A, Ishii KA, Chikamoto K, Kanamori T, Tajima N, Lan F, Takeshita Y, Honda M, Tanaka M, Kato S, Matsuyama N, Yoshioka Y, Iwayama K, Tokuyama K, Akazawa N, Maeda S, Takekoshi K, Matsugo S, Noguchi N, Kaneko S, Takamura T: Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle. Nat Med, 23(4):508-516, 2017.

1. Takehito Sugasawa, Naoki Mukai, Satoru Oshiro, Takafumi Handa, Ikumi Tanabe, Yuko Kumaki, Kyoko Tamura, Taiko Tanba, Norihiko Moriyama, Kazuhiro Takekoshi: The effects of cold stimulations of various temperatures on cell growth and metabolic activity of human cells in vitro, GAZZETTA MEDICA ITALIANA, 175(1-2): 15-22. 2016.
2. Takehito Sugasawa, Naoki Mukai, Kyoko Tamura, Taiko Tamba, Shintaro Mori, Yuki Miyashiro, Mami Yamaguchi, Norihiko Moriyama, Sumiko Nissato, Song-Gyu Ra, Yasuko Yoshida, Yasushi Kawakami, Kazuhiro Takekoshi. Effects of cold stimulation on mitochondrial activity and VEGF expression in vitro. Int J Sports Med. DOI: 10.1055/s-0042-102659.
3. 菅澤威仁, 向井直樹, 丹波泰子, 竹越一博・他: 異なる温度の冷却刺激が細胞のカタラーゼ活性に及ぼす影響, 理療, Vol .46, No. 1, 2016.
4. Takehito Sugasawa, Naoki Mukai, Kyoko Tamura, Kazuhiro Takekoshi et al. : Effect of closed fracture on spot urinary thiobarbituric acid reactive substance level in old rats. GAZZETTA MEDICA ITALIANA, 2016 (in press). 

1. 菅澤威仁, 井上知, 大塚絢香, 向井直樹, 丹波泰子, 竹越一博: マッサージ療法のエビデンス, 理療, Vol.44, No.4, pp72-81, 2015.
2. 菅澤威仁, 向井直樹, 丹波泰子, 田村京子, 森山紀彦, 竹越一博: 異なる温度の冷却刺激が細胞の代謝活性および増殖に及ぼす影響 -Rat Pheochromocytoma cellを用いた検討-, 理療, Vol.45, No.1, pp76-81, 2015. 
3. Youngju Choi, Masahiro Miura, Yoshio Nakata, Takehito Sugasawa, Sumiko Nissato, Takeshi Otsuki, Jun Sugawara, Yasushi Kawakami, Hitoshi Shimano, Yoshimi Iijima, Kiyoji Tanaka, Shinya Kuno, Nitish R. Mahapatra, Seiji Maeda, Kazuhiro Takekoshi. A common genetic variant of the chromogranin a-derived peptide catestatin is associated with atherogenesis and hypertension in a Japanese population. Endocrine Journal. doi: 10.1507/endocrj. EJ15-0471. 2015.
4. Saito Y, Ishii KA, Aita Y, Ikeda T, Kawakami Y, Shimano H, Hara H, Takekoshi K . Loss of SDHB Elevates Catecholamine Synthesis and Secretion Depending on ROS Production and HIF Stabilization. Neurochem Res. 2016 Apr;41(4):696-706. doi: 10.1007/s11064-015-1738-3. Epub 2015 Nov 30.

1. Tanaka Y, Isobe K, Enbo Ma, Imai T, Kikumori T, Matsuda T, Maeda Y, Sakurai A, Midorikawa S, Hataya Y, Kato T, Kamide K, Ikeda Y, Okada Y, Adachi M, Yanase T, Takahashi H, Yokoyama C, Arai Y, Hashimoto K, Shimano H, Hara H, Kawakami Y, Takekoshi K: Plasma Free Metanephrines in the Diagnosis of Pheochromocytoma: DiagnosticAccuracy and Strategies for Japanese Patients. Endocr J, 2014.

1. Ikeda T, Ishii KA, Saito Y, Miura M, Otagiri A, Kawakami Y, Shimano H, Hara H, Takekoshi K: Inhibition of autophagy enhances sunitinib-induced cytotoxicity in rat pheochromocytoma PC12 cells. J Pharmacol Sci, Vol.121,67-73, 2013.

1. Saito Y, Tanaka Y, Aita Y, Ishii KA, Ikeda T, Isobe K, Kawakami Y, Shimano H, Hara H, Takekoshi K: Sunitinib induces Apoptosis in Pheochromocytoma Tumor Cells by Inhibiting VEGFR2/AKT/mTOR/S6K1 Pathways Through Modulation of Bcl-2 and BAD. Am J Physiol Endocrinol Metab, vol.302, E615-625, 2012
2. Aita Y, shii KA, Ishii KA, Saito Y, Ikeda T, Kawakami Y, Shimano H, Takekoshi K:.Sunitinib Inhibits Catecholamine Synthesis and Secretion in Pheochromocytoma Tumor Cells by Blocking VEGF Receptor 2 via PLC-γ-related Pathways. Am J Physiol Endocrinol Metab, vol.303, E1006-14, 2012.
3. Takeichi N, Midorikawa S, Watanabe A, Naing BT, Tamura H, Kano T, Sugihara T, Nissato S, Saito Y, Aita Y, Ishii K, Igarashi T, Kawakami Y, Hara H, Ikeda T, Shimizu T, Suzuki S, Shimano H, Kawamoto M, Shimada T, Watanabe T, Oikawa S, Takekoshi K：Identical germline mutations in the TMEM127 gene in 2 unrelated Japanese patients with bilateral pheochromocytoma. Clin Endocrinol, vol.77, 707-14. 2012.

1. Tokinoya, K., Shiromoto, J., Sugasawa, T., Yoshida, Y., Ohmori, H., Takekoshi, K：Influence on renalase by acute exercise and its regulatory mechanism. The 23^th European College of Sport Science, Ireland(Dublin). 2018. 7.
2. 時野谷勝幸, 吉田保子, 菅澤威仁, 森田将平, 竹越一博：タウリン添加による代謝制御に関するマイオカインの応答．第4回国際タウリン研究会　日本部会，熊本，2018．3.
3. Katsuyuki Tokinoya, Yasuko Yoshida, Takehito Sugasawa, Yuichi Aita, Jun Shiromoto, Kai Aoki, Hajime Ohmori, Kazuhiro Takekoshi : Renalase might regulate catecholamine by skeletal muscle during exercise. The 22^ndShizuoka Forum on Health and Longevity, Shizuoka, 2017. 11.
4. 時野谷 勝幸，吉田 保子，菅澤 威仁，星野 雅也，石倉 惠介，大森 肇，竹越 一博：一過性の長距離走中における血中レナラーゼ濃度の変化. 第72回日本体力医学会大会，和歌山，2017.9.
5. 吉田 保子，菅澤 威仁，時野谷 勝幸，星野 雅也，難波 俊二，竹越 一博：筋細胞(L6 cell)における renalase 発現の検討. 第66回 日本医学検査学会，千葉，2017.6.
6. 菅澤威仁, 向井直樹, 丹波泰子, 田村京子, 吉田保子, 竹越一博: 異なる温度の冷却刺激が細胞のPGC1-αの発現に及ぼす影響 -フローサイトメトリーを用いた検討-,第65回日本理学療法学会, 静岡県清水市, 平成28年5月.
7. Takehito Sugasawa, Naoki Mukai, Kyoko Tamura, Taiko Tamba, Kazuhiro Takekoshi: The effects of cold stimulations of various temperatures on mitochondrial functions and biogenesis and expression of vascular endothelial growth factor (VEGF) of human cells in vitro, 第24回日本柔道整復接骨医学会学術大会, 新潟県新潟市, 平成27年11月.
8. Takehito Sugasawa, Taiko Tanba, Kyoko Tamura, Kazuhiro Takekoshi: The influence of fracture on the urinary thiobarbituric acid reactive substance (TBARS) in rats, 第23回日本柔道整復接骨医学会学術大会, 東京都大田区, 平成26年11月.
9. Takehito Sugasawa, Kazuhiro Takekoshi, Taiko Tanba, Kyoko Tamura, Takafumi Handa, Yuko Kumaki, Norihiko Moriyama, Naoki Mukai: The effects of cold stimulations of various temperatures on cell growth and metabolism activity for human cultured cells, 第87回日本生化学会大会, 京都府京都市, 平成26年10月. 
10. 菅澤威仁, 大城聰: ヒト培養細胞における異なる温度刺激が代謝活性に及ぼす影響 ─温熱療法および寒冷療法の検討─,第22回日本柔道整復接骨医学会学術大会, 東京都江東区, 平成25年11月.
11. Takehito Sugasawa, Taiko Tanba, Yuya Iwasawa, Takumi Sibuya, Kin-ya Hayakawa, Satoru Oshiro: Icing suppresses tissue damages and oxidative stress in a rat fracture rat model, 第21回日本柔道整復接骨医学会学術大会, 福岡県福岡市, 平成24年11月.
12. 菅澤威仁, 向井直樹, 丹波泰子, 田村京子, 竹越一博: 異なる温度の冷却刺激が細胞の抗酸化能に及ぼす影響-ヒト線維芽細胞を用いた検討-, 第64会日本理学療法学会, 愛媛県松山市, 平成27年5月.
13. 菅澤威仁, 竹越一博、向井直樹: 異なる冷却刺激が細胞の代謝活性および増殖に及ぼす影響 –ラット褐色細胞腫脂肪 (PC12 cell)を用いた検討, 関東甲信越理学療法学会, 長野県佐久平市, 2014年11月.